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Image Search Results
Journal: Frontiers in Neuroscience
Article Title: Electro-Acupuncture Ameliorated MPTP-Induced Parkinsonism in Mice via TrkB Neurotrophic Signaling
doi: 10.3389/fnins.2019.00496
Figure Lengend Snippet: EA ameliorated the deficit of motor functions in MPTP-lesioned mouse model (A) Experimental design. Mice were randomly divided into three groups: vehicle control, MPTP+sham EA, MPTP+EA. Mice received MPTP (25 mg/kg/day) for 7 consecutive days. EA treatment was carried out at 4 h before MPTP injection. After one-week treatment, mice were kept for 3 days and assessed by behavioral test and biochemical analysis. (B) Diagram for EA stimulation. EA was applied at GV20 and GV29. Needles were inserted into acupoint at 3 mm under the skin. The electrodes were connected to the needles and secured with a plastic wire. EA was carried out for 10 min per session. (C) Rotarod test performance to assess the behavior impairments. The on-rotarod time for mice was recorded. (D) Tail suspension test. The immobility time for mice was recorded over 6 min. The results were presented as mean ± SEM from 3 independent experiments ( n = 10), ∗∗ p < 0.01, ∗∗∗ p < 0.001.
Article Snippet: Mice were assessed for MPTP-triggered parkinsonism impairments by a
Techniques: Injection
Journal: Frontiers in Neuroscience
Article Title: Electro-Acupuncture Ameliorated MPTP-Induced Parkinsonism in Mice via TrkB Neurotrophic Signaling
doi: 10.3389/fnins.2019.00496
Figure Lengend Snippet: The administration of TrkB inhibitor K252a effectively abolished the effect of EA on MPTP impaired the motor function. 1 h prior to each EA session, K252a (5 μg/kg/day) or vehicle was administered to mice via i.p. injection. (A) The effect of K252a on rotarod performance test. The rodding time of each mice were analyzed. (B) The behavioral deficits were assessed by tail suspension test. The immobility time of each mice within 6-min were recorded. The results were presented as mean ± SEM from 3 independent experiments ( n = 10). ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001.
Article Snippet: Mice were assessed for MPTP-triggered parkinsonism impairments by a
Techniques: Injection